6nbh: Difference between revisions

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<SX load='6nbh' size='340' side='right' viewer='molstar' caption='[[6nbh]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<SX load='6nbh' size='340' side='right' viewer='molstar' caption='[[6nbh]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6nbh]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovin Bovin], [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat], [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Synthetic_construct_sequences Synthetic construct sequences]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6NBH FirstGlance]. <br>
<table><tr><td colspan='2'>[[6nbh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NBH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6NBH FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTH1R, PTHR, PTHR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Gnb1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 BOVIN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6nbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbh OCA], [http://pdbe.org/6nbh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nbh RCSB], [http://www.ebi.ac.uk/pdbsum/6nbh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbh ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6nbh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nbh OCA], [https://pdbe.org/6nbh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6nbh RCSB], [https://www.ebi.ac.uk/pdbsum/6nbh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6nbh ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] Blomstrand lethal chondrodysplasia;Dental ankylosis;Eiken syndrome;Metaphyseal chondrodysplasia, Jansen type;Enchondromatosis. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease may be caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[[http://www.uniprot.org/uniprot/GBB1_RAT GBB1_RAT]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [[http://www.uniprot.org/uniprot/PTH1R_HUMAN PTH1R_HUMAN]] This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.<ref>PMID:18611381</ref> <ref>PMID:20172855</ref>  [[http://www.uniprot.org/uniprot/GBG2_BOVIN GBG2_BOVIN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Bovin]]
[[Category: Bos taurus]]
[[Category: Buffalo rat]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Synthetic construct sequences]]
[[Category: Rattus norvegicus]]
[[Category: Clark, L J]]
[[Category: Synthetic construct]]
[[Category: Gardella, T J]]
[[Category: Clark LJ]]
[[Category: Jean-Alphonse, F G]]
[[Category: Gardella TJ]]
[[Category: Jiang, Y]]
[[Category: Jean-Alphonse FG]]
[[Category: Kang, Y]]
[[Category: Jiang Y]]
[[Category: Li, C Y]]
[[Category: Kang Y]]
[[Category: Ma, S]]
[[Category: Li C-Y]]
[[Category: Melcher, K]]
[[Category: Ma S]]
[[Category: Shen, D D]]
[[Category: Melcher K]]
[[Category: Sutkeviciute, I]]
[[Category: Shen D-D]]
[[Category: Vilardaga, J P]]
[[Category: Sutkeviciute I]]
[[Category: Waal, P P.de]]
[[Category: Vilardaga J-P]]
[[Category: Wang, M W]]
[[Category: Wang M-W]]
[[Category: Watanabe, T]]
[[Category: Watanabe T]]
[[Category: White, A D]]
[[Category: White AD]]
[[Category: Xiao, K]]
[[Category: Xiao K]]
[[Category: Xu, H E]]
[[Category: Xu HE]]
[[Category: Yang, D]]
[[Category: Yang D]]
[[Category: Zhang, Y]]
[[Category: Zhang Y]]
[[Category: Zhao, L H]]
[[Category: Zhao L-H]]
[[Category: Zhou, X E]]
[[Category: Zhou XE]]
[[Category: Class b gpcr]]
[[Category: De Waal PP]]
[[Category: Gpcr]]
[[Category: Gpcr-g protein complex]]
[[Category: Parathyroid hormone receptor]]
[[Category: Signaling protein]]
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