1tow: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1tow.gif|left|200px]] | [[Image:1tow.gif|left|200px]] | ||
<!-- | |||
The line below this paragraph, containing "STRUCTURE_1tow", creates the "Structure Box" on the page. | |||
You may change the PDB parameter (which sets the PDB file loaded into the applet) | |||
or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |||
| | or leave the SCENE parameter empty for the default display. | ||
| | --> | ||
{{STRUCTURE_1tow| PDB=1tow | SCENE= }} | |||
}} | |||
'''Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand''' | '''Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand''' | ||
| Line 34: | Line 31: | ||
[[Category: Svensson, S.]] | [[Category: Svensson, S.]] | ||
[[Category: Uppenberg, J.]] | [[Category: Uppenberg, J.]] | ||
[[Category: | [[Category: Lipid-binding]] | ||
[[Category: | [[Category: Transport]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 10:12:15 2008'' | |||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | |||
Revision as of 07:12, 3 May 2008
Crystal structure of human adipocyte fatty acid binding protein in complex with a carboxylic acid ligand
Overview
Low micromolar human A-FABP inhibitors were found by utilizing a fluorescence polarization assay, X-ray crystallography and modeling. The carbazole- and indole-based inhibitors displayed approximately 10-fold preferences over human H-FABP and E-FABP, and are highly selective against I-FABP. This communication describes the SAR for drug-like synthetic inhibitors of human A-FABP.
About this Structure
1TOW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Discovery of inhibitors of human adipocyte fatty acid-binding protein, a potential type 2 diabetes target., Lehmann F, Haile S, Axen E, Medina C, Uppenberg J, Svensson S, Lundback T, Rondahl L, Barf T, Bioorg Med Chem Lett. 2004 Sep 6;14(17):4445-8. PMID:15357969 Page seeded by OCA on Sat May 3 10:12:15 2008
