5vh9: Difference between revisions

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<SX load='5vh9' size='340' side='right' viewer='molstar' caption='[[5vh9]], [[Resolution|resolution]] 7.70&Aring;' scene=''>
<SX load='5vh9' size='340' side='right' viewer='molstar' caption='[[5vh9]], [[Resolution|resolution]] 7.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5vh9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VH9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5VH9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5vh9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VH9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5VH9 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vlj|5vlj]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DYN1, DHC1, YKR054C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824]), PAC1, LIS1, SCY_5321 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5vh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vh9 OCA], [https://pdbe.org/5vh9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5vh9 RCSB], [https://www.ebi.ac.uk/pdbsum/5vh9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5vh9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5vh9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vh9 OCA], [http://pdbe.org/5vh9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vh9 RCSB], [http://www.ebi.ac.uk/pdbsum/5vh9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vh9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DYHC_YEAST DYHC_YEAST]] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.<ref>PMID:15642746</ref> [[http://www.uniprot.org/uniprot/LIS1_YEAS7 LIS1_YEAS7]] Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.
[https://www.uniprot.org/uniprot/DYHC_YEAST DYHC_YEAST] Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.<ref>PMID:15642746</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</SX>
</SX>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cianfrocco, M A]]
[[Category: Saccharomyces cerevisiae]]
[[Category: DeSantis, M E]]
[[Category: Cianfrocco MA]]
[[Category: Htet, Z M]]
[[Category: DeSantis ME]]
[[Category: Leschziner, A E]]
[[Category: Htet ZM]]
[[Category: Reck-Peterson, S L]]
[[Category: Leschziner AE]]
[[Category: Tran, P T]]
[[Category: Reck-Peterson SL]]
[[Category: Cytoplasmic dynein]]
[[Category: Tran PT]]
[[Category: Lis1]]
[[Category: Motor protein]]

Latest revision as of 09:30, 23 October 2024

Cryo-EM structure of yeast cytoplasmic dynein-1 with Lis1 and ATP

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