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==PICK1 PDZ domain in complex with the class I PDZ binding motif QSAV==
==PICK1 PDZ domain in complex with the class I PDZ binding motif QSAV==
<StructureSection load='6bjn' size='340' side='right' caption='[[6bjn]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
<StructureSection load='6bjn' size='340' side='right'caption='[[6bjn]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6bjn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BJN FirstGlance]. <br>
<table><tr><td colspan='2'>[[6bjn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BJN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BJN FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PICK1, PRKCABP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bjn OCA], [http://pdbe.org/6bjn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bjn RCSB], [http://www.ebi.ac.uk/pdbsum/6bjn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bjn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bjn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bjn OCA], [https://pdbe.org/6bjn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bjn RCSB], [https://www.ebi.ac.uk/pdbsum/6bjn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bjn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PICK1_HUMAN PICK1_HUMAN]] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.<ref>PMID:20403402</ref>
[https://www.uniprot.org/uniprot/PICK1_HUMAN PICK1_HUMAN] Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate heteromeric ASIC1/ASIC3 channel.<ref>PMID:20403402</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Marcotte, D J]]
[[Category: Large Structures]]
[[Category: Peptide binding protein]]
[[Category: Marcotte DJ]]
[[Category: Pick1 pdz domain class ii pdz binding motif]]
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