6cmo: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<SX load='6cmo' size='340' side='right' viewer='molstar' caption='[[6cmo]], [[Resolution|resolution]] 4.50Å' scene=''> | <SX load='6cmo' size='340' side='right' viewer='molstar' caption='[[6cmo]], [[Resolution|resolution]] 4.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6cmo]] is a 6 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6cmo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6CMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6CMO FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cmo OCA], [https://pdbe.org/6cmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6cmo RCSB], [https://www.ebi.ac.uk/pdbsum/6cmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6cmo ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/OPSD_HUMAN OPSD_HUMAN] Congenital stationary night blindness;Retinitis punctata albescens;Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/OPSD_HUMAN OPSD_HUMAN] Photoreceptor required for image-forming vision at low light intensity (PubMed:7846071, PubMed:8107847). Required for photoreceptor cell viability after birth (PubMed:12566452, PubMed:2215617). Light-induced isomerization of the chromophore 11-cis-retinal to all-trans-retinal triggers a conformational change that activates signaling via G-proteins (PubMed:26200343, PubMed:28524165, PubMed:28753425, PubMed:8107847). Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling (PubMed:26200343, PubMed:28524165).<ref>PMID:12566452</ref> <ref>PMID:2215617</ref> <ref>PMID:26200343</ref> <ref>PMID:28753425</ref> <ref>PMID:7846071</ref> <ref>PMID:8107847</ref> <ref>PMID:28524165</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 21: | Line 23: | ||
==See Also== | ==See Also== | ||
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | |||
*[[Transducin 3D structures|Transducin 3D structures]] | *[[Transducin 3D structures|Transducin 3D structures]] | ||
== References == | == References == | ||
| Line 26: | Line 29: | ||
__TOC__ | __TOC__ | ||
</SX> | </SX> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: Homo sapiens]] | |||
[[Category: | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Bartesaghi A]] | ||
[[Category: | [[Category: Dutka P]] | ||
[[Category: | [[Category: Earnst OP]] | ||
[[Category: Erramilli | [[Category: Erramilli S]] | ||
[[Category: Gu | [[Category: Gu X]] | ||
[[Category: Jiang | [[Category: Jiang Y]] | ||
[[Category: Kang | [[Category: Kang Y]] | ||
[[Category: Kossiakoff | [[Category: Kossiakoff AA]] | ||
[[Category: Kuybeda | [[Category: Kuybeda O]] | ||
[[Category: Liu | [[Category: Liu P]] | ||
[[Category: Melcher | [[Category: Melcher K]] | ||
[[Category: Meng | [[Category: Meng X]] | ||
[[Category: Morizumi | [[Category: Morizumi T]] | ||
[[Category: Mukherjee | [[Category: Mukherjee S]] | ||
[[Category: Subramaniam | [[Category: Subramaniam S]] | ||
[[Category: | [[Category: Van Eps N]] | ||
[[Category: Xu | [[Category: Xu HE]] | ||
[[Category: Yin | [[Category: Yin Y]] | ||
[[Category: Zhao | [[Category: Zhao G]] | ||
[[Category: Zhou | [[Category: Zhou XE]] | ||
[[Category: | [[Category: De Waal PW]] | ||