6g8z: Difference between revisions

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<SX load='6g8z' size='340' side='right' viewer='molstar' caption='[[6g8z]], [[Resolution|resolution]] 3.66&Aring;' scene=''>
<SX load='6g8z' size='340' side='right' viewer='molstar' caption='[[6g8z]], [[Resolution|resolution]] 3.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6g8z]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G8Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6G8Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[6g8z]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G8Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G8Z FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Lrrc8a, Lrrc8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.66&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6g8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g8z OCA], [http://pdbe.org/6g8z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g8z RCSB], [http://www.ebi.ac.uk/pdbsum/6g8z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g8z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g8z OCA], [https://pdbe.org/6g8z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g8z RCSB], [https://www.ebi.ac.uk/pdbsum/6g8z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g8z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE]] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref>
[https://www.uniprot.org/uniprot/LRC8A_MOUSE LRC8A_MOUSE] Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro) (By similarity). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746, PubMed:24752297). Also required for T-cell development (PubMed:24752297).[UniProtKB:Q8IWT6]<ref>PMID:14660746</ref> <ref>PMID:24752297</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</SX>
</SX>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Deneka, D]]
[[Category: Deneka D]]
[[Category: Dutzler, R]]
[[Category: Dutzler R]]
[[Category: Lam, A K.M]]
[[Category: Lam AKM]]
[[Category: Paulino, C]]
[[Category: Paulino C]]
[[Category: Sawicka, M]]
[[Category: Sawicka M]]
[[Category: Chloride channel]]
[[Category: Leucine-rich repeat]]
[[Category: Membrane protein]]
[[Category: Swelling-activated]]
[[Category: Vsoac]]
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