6o0t: Difference between revisions

<table><tr><td colspan='2'>[[6o0t]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6O0T FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6o0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o0t OCA], [https://pdbe.org/6o0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6o0t RCSB], [https://www.ebi.ac.uk/pdbsum/6o0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6o0t ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>  

[[Category: Homo sapiens]]

[[Category: Boden M]]

[[Category: Bosanac T]]

[[Category: Burdett H]]

[[Category: Casey L]]

[[Category: Chen J]]

[[Category: Coleman MP]]

[[Category: Deerain N]]

[[Category: Dodds PN]]

[[Category: Dry IB]]

[[Category: Ericsson DJ]]

[[Category: Foley G]]

[[Category: Gilley J]]

[[Category: Gu W]]

[[Category: Horsefield S]]

[[Category: Hughes RO]]

[[Category: Kobe B]]

[[Category: Lai J]]

[[Category: Manik MK]]

[[Category: Nanson JD]]

[[Category: Rank M]]

[[Category: Rathjen JP]]

[[Category: Shi Y]]

[[Category: Staskawicz BJ]]

[[Category: Tiancong Q]]

[[Category: Ve T]]

[[Category: Williams SJ]]

[[Category: Zhang X]]

[[Category: Von Itzstein M]]