6zt0: Difference between revisions

[https://www.uniprot.org/uniprot/EIGER_DROME EIGER_DROME] Cytokine which acts as a ligand for wgn (PubMed:12894227). Also acts as a ligand for grnd (PubMed:25874673). Induces apoptosis by triggering JNK signaling (PubMed:12176339, PubMed:12065414, PubMed:12894227). Required for JNK-dependent non-autonomous apoptosis through release from apoptotic cells and activation of apoptosis in neighboring cells (PubMed:24066226). Required for JNK-independent damage-induced apoptosis in the embryonic central nervous system through regulation of the pro-apoptotic gene hid (PubMed:25754009). Involved in the innate immune response to extracellular pathogens (PubMed:17381241). Plays a role in the melanization immune response through its involvement in the rupture of crystal cells and subsequent release of prophenoloxidase (PubMed:17356067). Following UV-induced epidermal damage, released from apoptotic epidermal cells, binds to the wgn receptor on nociceptive sensory neurons and plays a role in development of thermal allodynia, a responsiveness to subthreshold thermal stimuli which are not normally perceived as noxious (PubMed:19375319). Involved in glial cell division induced by neuronal programmed cell death and injury (PubMed:19019992). Has tumor suppressor activity and eliminates oncogenic cells from epithelia, thereby maintaining epithelial integrity (PubMed:19289090).<ref>PMID:12065414</ref> <ref>PMID:12176339</ref> <ref>PMID:12894227</ref> <ref>PMID:17356067</ref> <ref>PMID:17381241</ref> <ref>PMID:19019992</ref> <ref>PMID:19289090</ref> <ref>PMID:19375319</ref> <ref>PMID:24066226</ref> <ref>PMID:25754009</ref> <ref>PMID:25874673</ref>