1tvk: Difference between revisions

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[[Image:1tvk.gif|left|200px]]
[[Image:1tvk.gif|left|200px]]


{{Structure
<!--
|PDB= 1tvk |SIZE=350|CAPTION= <scene name='initialview01'>1tvk</scene>, resolution 2.89&Aring;
The line below this paragraph, containing "STRUCTURE_1tvk", creates the "Structure Box" on the page.
|SITE=
You may change the PDB parameter (which sets the PDB file loaded into the applet)
|LIGAND= <scene name='pdbligand=EP:EPOTHILONE+A'>EP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5&#39;-TRIPHOSPHATE'>GTP</scene>
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
|ACTIVITY=  
or leave the SCENE parameter empty for the default display.
|GENE=  
-->
|DOMAIN=
{{STRUCTURE_1tvk| PDB=1tvk  | SCENE= }}  
|RELATEDENTRY=[[1jff|1JFF]], [[1tub|1TUB]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tvk OCA], [http://www.ebi.ac.uk/pdbsum/1tvk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1tvk RCSB]</span>
}}


'''The binding mode of epothilone A on a,b-tubulin by electron crystallography'''
'''The binding mode of epothilone A on a,b-tubulin by electron crystallography'''
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[[Category: Nettles, J H.]]
[[Category: Nettles, J H.]]
[[Category: Snyder, J P.]]
[[Category: Snyder, J P.]]
[[Category: epothilone]]
[[Category: Epothilone]]
[[Category: ligand interaction]]
[[Category: Ligand interaction]]
[[Category: taxol]]
[[Category: Taxol]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:25:25 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:01:40 2008''

Revision as of 07:25, 3 May 2008

File:1tvk.gif

Template:STRUCTURE 1tvk

The binding mode of epothilone A on a,b-tubulin by electron crystallography


Overview

The structure of epothilone A, bound to alpha,beta-tubulin in zinc-stabilized sheets, was determined by a combination of electron crystallography at 2.89 angstrom resolution and nuclear magnetic resonance-based conformational analysis. The complex explains both the broad-based epothilone structure-activity relationship and the known mutational resistance profile. Comparison with Taxol shows that the longstanding expectation of a common pharmacophore is not met, because each ligand exploits the tubulin-binding pocket in a unique and independent manner.

About this Structure

1TVK is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography., Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH, Science. 2004 Aug 6;305(5685):866-9. PMID:15297674 Page seeded by OCA on Sat May 3 10:25:25 2008

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