2kb6: Difference between revisions
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==Solution structure of onconase C87A/C104A== | ==Solution structure of onconase C87A/C104A== | ||
<StructureSection load='2kb6' size='340' side='right'caption='[[2kb6 | <StructureSection load='2kb6' size='340' side='right'caption='[[2kb6]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2kb6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2kb6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lithobates_pipiens Lithobates pipiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KB6 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kb6 OCA], [https://pdbe.org/2kb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kb6 RCSB], [https://www.ebi.ac.uk/pdbsum/2kb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kb6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kb6 OCA], [https://pdbe.org/2kb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kb6 RCSB], [https://www.ebi.ac.uk/pdbsum/2kb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kb6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/RNP30_LITPI RNP30_LITPI] Basic protein with antiproliferative/cytotoxic activity against several tumor cell lines in vitro, as well as antitumor in vivo. It exhibits a ribonuclease-like activity against high molecular weight ribosomal RNA. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kb6_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/2kb6_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Lithobates pipiens]] | ||
[[Category: Arnold | [[Category: Arnold U]] | ||
[[Category: Balbach | [[Category: Balbach J]] | ||
[[Category: Schulenburg | [[Category: Schulenburg C]] | ||
[[Category: Ulbrich-Hofmann | [[Category: Ulbrich-Hofmann R]] | ||
[[Category: Weininger | [[Category: Weininger U]] | ||
