2kd3: Difference between revisions

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==NMR structure of the Wnt modulator protein Sclerostin==
==NMR structure of the Wnt modulator protein Sclerostin==
<StructureSection load='2kd3' size='340' side='right'caption='[[2kd3]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='2kd3' size='340' side='right'caption='[[2kd3]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KD3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KD3 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kd3 OCA], [https://pdbe.org/2kd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kd3 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kd3 OCA], [https://pdbe.org/2kd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2kd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kd3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SOST_MOUSE SOST_MOUSE] Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.<ref>PMID:19419300</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kd3_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kd3_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Mueller, T D]]
[[Category: Mueller TD]]
[[Category: Weidauer, S E]]
[[Category: Weidauer SE]]
[[Category: Antagonist of cytokine]]
[[Category: Protein]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/2kd3"