3l2p: Difference between revisions

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==Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States==
==Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States==
<StructureSection load='3l2p' size='340' side='right' caption='[[3l2p]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='3l2p' size='340' side='right'caption='[[3l2p]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3l2p]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L2P FirstGlance]. <br>
<table><tr><td colspan='2'>[[3l2p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L2P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L2P FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2p OCA], [https://pdbe.org/3l2p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l2p RCSB], [https://www.ebi.ac.uk/pdbsum/3l2p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l2p ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l2p OCA], [http://pdbe.org/3l2p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3l2p RCSB], [http://www.ebi.ac.uk/pdbsum/3l2p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3l2p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN]] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.  
[https://www.uniprot.org/uniprot/DNLI3_HUMAN DNLI3_HUMAN] Interacts with DNA-repair protein XRCC1 and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/3l2p_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/3l2p_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[DNA ligase|DNA ligase]]
*[[DNA ligase 3D structures|DNA ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Cotner-Gohara, E A]]
[[Category: Large Structures]]
[[Category: Ellenberger, T]]
[[Category: Cotner-Gohara EA]]
[[Category: Hammel, M]]
[[Category: Ellenberger T]]
[[Category: Kim, I K]]
[[Category: Hammel M]]
[[Category: Tainer, J A]]
[[Category: Kim IK]]
[[Category: Tomkinson, A]]
[[Category: Tainer JA]]
[[Category: Atp-binding]]
[[Category: Tomkinson A]]
[[Category: Cell cycle]]
[[Category: Cell division]]
[[Category: Dna damage]]
[[Category: Dna ligase]]
[[Category: Dna recombination]]
[[Category: Dna repair]]
[[Category: Dna replication]]
[[Category: Ligase]]
[[Category: Ligase-dna complex]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Nucleotide-binding]]
[[Category: Nucleus]]
[[Category: Phosphoprotein]]
[[Category: Zinc-finger]]

Latest revision as of 09:22, 30 October 2024

Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States

3l2p, resolution 3.00Å

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