6kle: Difference between revisions

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<StructureSection load='6kle' size='340' side='right'caption='[[6kle]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
<StructureSection load='6kle' size='340' side='right'caption='[[6kle]], [[Resolution|resolution]] 4.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6kle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Machu Machu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KLE FirstGlance]. <br>
<table><tr><td colspan='2'>[[6kle]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mammarenavirus_machupoense Mammarenavirus machupoense] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KLE FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kle OCA], [https://pdbe.org/6kle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kle RCSB], [https://www.ebi.ac.uk/pdbsum/6kle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kle ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6kle FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kle OCA], [https://pdbe.org/6kle PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6kle RCSB], [https://www.ebi.ac.uk/pdbsum/6kle PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6kle ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/Q6IVU0_MACHU Q6IVU0_MACHU]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[HAMAP-Rule:MF_04086][PIRNR:PIRNR000836]  
[https://www.uniprot.org/uniprot/Q6IVU0_MACHU Q6IVU0_MACHU] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[HAMAP-Rule:MF_04086][PIRNR:PIRNR000836]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Machu]]
[[Category: Mammarenavirus machupoense]]
[[Category: Gao, G F]]
[[Category: Synthetic construct]]
[[Category: Jing, J]]
[[Category: Gao GF]]
[[Category: Peng, Q]]
[[Category: Jing J]]
[[Category: Peng, R]]
[[Category: Peng Q]]
[[Category: Shi, Y]]
[[Category: Peng R]]
[[Category: Xu, X]]
[[Category: Shi Y]]
[[Category: Polymerase]]
[[Category: Xu X]]
[[Category: Rna virus]]
[[Category: Viral protein]]
[[Category: Viral protein-rna complex]]
Retrieved from "https://proteopedia.org/6kle"