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==Crystal Structure of HIV-1 B41 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-386150 in Complex with Human Antibodies 3H109L and 35O22 at 3.8 Angstrom==
==Crystal Structure of HIV-1 B41 SOSIP.664 Prefusion Env Trimer Bound to Small Molecule HIV-1 Entry Inhibitor BMS-386150 in Complex with Human Antibodies 3H109L and 35O22 at 3.8 Angstrom==
<StructureSection load='6mug' size='340' side='right' caption='[[6mug]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
<StructureSection load='6mug' size='340' side='right'caption='[[6mug]], [[Resolution|resolution]] 2.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6mug]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MUG FirstGlance]. <br>
<table><tr><td colspan='2'>[[6mug]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MUG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6MUG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=JYS:1-[4-(benzenecarbonyl)piperazin-1-yl]-2-(4-bromo-7-fluoro-1H-indol-3-yl)ethane-1,2-dione'>JYS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.954&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mug OCA], [http://pdbe.org/6mug PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mug RCSB], [http://www.ebi.ac.uk/pdbsum/6mug PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mug ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=JYS:1-(4-bromanyl-7-fluoranyl-1~{H}-indol-3-yl)-2-[4-(phenylcarbonyl)piperazin-1-yl]ethane-1,2-dione'>JYS</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6mug FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mug OCA], [https://pdbe.org/6mug PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6mug RCSB], [https://www.ebi.ac.uk/pdbsum/6mug PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6mug ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/B3UEZ6_9HIV1 B3UEZ6_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6mug" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6mug" style="background-color:#fffaf0;"></div>
==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Kwong, P D]]
[[Category: Homo sapiens]]
[[Category: Lai, Y T]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Entry inhibitor]]
[[Category: Large Structures]]
[[Category: Hiv-1 envelope prefusion trimer]]
[[Category: Kwong PD]]
[[Category: Immune system-inhibitor complex]]
[[Category: Lai Y-T]]
Retrieved from "https://proteopedia.org/6mug"