8kex: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8kex is ~~ON HOLD until 2026~~-02-14

==CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8kex]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria], [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KEX OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8KEX FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JW0:(4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic+acid'>JW0</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8kex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kex OCA], [https://pdbe.org/8kex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kex RCSB], [https://www.ebi.ac.uk/pdbsum/8kex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kex ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.[https://www.uniprot.org/uniprot/MRGX4_HUMAN MRGX4_HUMAN] Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).

__TOC__

</StructureSection>

[[Category: Aequorea victoria]]

[[Category: Escherichia coli]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Fan JP]]

[[Category: Lei XG]]

[[Category: Yang J]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8kex is ON HOLD  until 2026-02-14
+==CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local==
+<StructureSection load='8kex' size='340' side='right'caption='[[8kex]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8kex]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aequorea_victoria Aequorea victoria], [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KEX FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JW0:(4~{R})-4-[(3~{R},5~{R},8~{R},9~{S},10~{S},12~{S},13~{R},14~{S},17~{R})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{H}-cyclopenta[a]phenanthren-17-yl]pentanoic+acid'>JW0</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kex OCA], [https://pdbe.org/8kex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kex RCSB], [https://www.ebi.ac.uk/pdbsum/8kex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kex ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/GFP_AEQVI GFP_AEQVI] Energy-transfer acceptor. Its role is to transduce the blue chemiluminescence of the protein aequorin into green fluorescent light by energy transfer. Fluoresces in vivo upon receiving energy from the Ca(2+)-activated photoprotein aequorin.[https://www.uniprot.org/uniprot/MRGX4_HUMAN MRGX4_HUMAN] Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Aequorea victoria]]
+[[Category: Escherichia coli]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Fan JP]]
+[[Category: Lei XG]]
+[[Category: Yang J]]