2l27: Difference between revisions
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==NMR Structure of the ECD1 of CRF-R1 in complex with a peptide agonist== | ==NMR Structure of the ECD1 of CRF-R1 in complex with a peptide agonist== | ||
<StructureSection load='2l27' size='340' side='right'caption='[[2l27 | <StructureSection load='2l27' size='340' side='right'caption='[[2l27]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2l27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2l27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L27 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l27 OCA], [https://pdbe.org/2l27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l27 RCSB], [https://www.ebi.ac.uk/pdbsum/2l27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l27 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l27 OCA], [https://pdbe.org/2l27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l27 RCSB], [https://www.ebi.ac.uk/pdbsum/2l27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l27 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CRFR1_HUMAN CRFR1_HUMAN] Receptor for corticotropin releasing factor (CRH). Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:18801728</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/2l27_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/2l27_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Grace | [[Category: Grace CRR]] | ||
[[Category: Gulyas | [[Category: Gulyas JRR]] | ||
[[Category: Perrin | [[Category: Perrin MH]] | ||
[[Category: Riek | [[Category: Riek RR]] | ||
[[Category: Rivier | [[Category: Rivier JE]] | ||
[[Category: Vale | [[Category: Vale WW]] | ||
