3v0a: Difference between revisions

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<StructureSection load='3v0a' size='340' side='right'caption='[[3v0a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3v0a' size='340' side='right'caption='[[3v0a]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3v0a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896] and [https://en.wikipedia.org/wiki/Camelus_glama Camelus glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V0A FirstGlance]. <br>
<table><tr><td colspan='2'>[[3v0a]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V0A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V0A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.703&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3v0b|3v0b]], [[3v0c|3v0c]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bont/a, boNT/A, bonta ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896]), ant, ntnh ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1491 "Bacillus botulinus" van Ermengem 1896])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0a OCA], [https://pdbe.org/3v0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v0a RCSB], [https://www.ebi.ac.uk/pdbsum/3v0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v0a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v0a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v0a OCA], [https://pdbe.org/3v0a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v0a RCSB], [https://www.ebi.ac.uk/pdbsum/3v0a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v0a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/BXAN_CLOBO BXAN_CLOBO] Assembles with botulinum neurotoxin type A (BoNT/A) and protects it against pH-mediated inactivation or protease activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not at pH 6.0 (PubMed:22363010). Necessary for neurotoxicity.<ref>PMID:22363010</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus botulinus van ermengem 1896]]
[[Category: Clostridium botulinum]]
[[Category: Camelus glama]]
[[Category: Lama glama]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bigalke, H]]
[[Category: Bigalke H]]
[[Category: Gu, S]]
[[Category: Gu S]]
[[Category: Jin, R]]
[[Category: Jin R]]
[[Category: Perry, K]]
[[Category: Perry K]]
[[Category: Rummel, A]]
[[Category: Rummel A]]
[[Category: Rumpel, S]]
[[Category: Rumpel S]]
[[Category: Shoemaker, C B]]
[[Category: Shoemaker CB]]
[[Category: Strotmeier, J]]
[[Category: Strotmeier J]]
[[Category: Zhou, J]]
[[Category: Zhou J]]
[[Category: Botulinum neurotoxin]]
[[Category: Neurotoxin associated protein]]
[[Category: Ntnha]]
[[Category: Progenitor toxin complex]]
[[Category: Toxin]]
[[Category: Vhh bound interlocked complex]]
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