4mn4: Difference between revisions

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== Function ==

[https://www.uniprot.org/uniprot/~~PARC_ECOLI PARC_ECOLI~~] ~~Topoisomerase IV~~ is essential for chromosome ~~segregation~~. ~~It relaxes supercoiled~~ DNA. ~~Performs the decatenation events required during the replication~~ of a ~~circular~~ DNA ~~molecule. MukB stimulates the~~ relaxation activity of topoisomerase IV ~~and also has a modest effect on decatenation~~.<ref>PMID:20921377</ref> <ref>PMID:~~12269820</ref> <ref>PMID:21300644</ref> <ref>PMID:16023670~~</ref>

[https://www.uniprot.org/uniprot/MUKB_ECOLI MUKB_ECOLI] Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV.<ref>PMID:20921377</ref> <ref>PMID:10660686</ref>

== Publication Abstract from PubMed ==

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 </table>
 == Function ==
-[https://www.uniprot.org/uniprot/PARC_ECOLI PARC_ECOLI] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.<ref>PMID:20921377</ref> <ref>PMID:12269820</ref> <ref>PMID:21300644</ref> <ref>PMID:16023670</ref>
+[https://www.uniprot.org/uniprot/MUKB_ECOLI MUKB_ECOLI] Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV.<ref>PMID:20921377</ref> <ref>PMID:10660686</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==