5m5x: Difference between revisions

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== Function ==

[https://www.uniprot.org/uniprot/~~RPA1_YEAST RPA1_YEAST~~] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. ~~Largest and catalytic core~~ component of RNA ~~polymerase~~ I which ~~synthesizes~~ ribosomal RNA precursors. ~~Forms~~ the ~~polymerase active center together~~ with ~~the second largest subunit. A single stranded DNA template strand of the promoter is positioned within~~ the central ~~active site~~ cleft ~~of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site~~ and ~~is thought to promote translocation of Pol I by acting as~~ a ~~ratchet~~ that moves the ~~RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition~~ (By similarity).

[https://www.uniprot.org/uniprot/RPAC1_YEAST RPAC1_YEAST] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).

== Publication Abstract from PubMed ==

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 </table>
 == Function ==
-[https://www.uniprot.org/uniprot/RPA1_YEAST RPA1_YEAST] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Forms the polymerase active center together with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I. A bridging helix emanates from RPA1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol I by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition (By similarity).
+[https://www.uniprot.org/uniprot/RPAC1_YEAST RPAC1_YEAST] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==