8dc5: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[8dc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Crimean-Congo_hemorrhagic_fever_orthonairovirus Crimean-Congo hemorrhagic fever orthonairovirus~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DC5 FirstGlance]. <br>

<table><tr><td colspan='2'>[[8dc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthonairovirus_haemorrhagiae Orthonairovirus haemorrhagiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DC5 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.21Å</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>

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</table>

== Function ==

[https://www.uniprot.org/uniprot/A0A7T6Y557_9VIRU A0A7T6Y557_9VIRU] ~~Glycoprotein C~~ and ~~glycoprotein N interact with each other~~ and ~~are present at the surface of the virion~~. ~~They are able to attach the virion~~ to ~~host cell receptors. This attachment~~ induces virion internalization predominantly through clathrin-dependent endocytosis. ~~Also~~ promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion.[PIRNR:PIRNR003962]

[https://www.uniprot.org/uniprot/A0A7T6Y557_9VIRU A0A7T6Y557_9VIRU] Binds to host cell surface receptor LDLR and mediates fusion between viral and cellular membranes. Attachment to receptor induces virion internalization predominantly through clathrin-dependent endocytosis. Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Exposure of the glycoprotein spikes to potassium is necessary for the conformational change leading to fusion.[PIRNR:PIRNR003962] Plays a role in virion attachment to host receptor. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Glycoprotein N probably locks the Gn-Gc complex in a prefusion state.[PIRNR:PIRNR003962]

== Publication Abstract from PubMed ==

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__TOC__

</StructureSection>

~~[[Category: Crimean-Congo hemorrhagic fever orthonairovirus]]~~

[[Category: Large Structures]]

[[Category: Orthonairovirus haemorrhagiae]]

[[Category: Bergeron E]]

[[Category: Durie IA]]

[[Category: McGuire J]]

[[Category: Pegan SD]]

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@@ Line 3: / Line 3: @@
 <StructureSection load='8dc5' size='340' side='right'caption='[[8dc5]], [[Resolution|resolution]] 3.21&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[8dc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Crimean-Congo_hemorrhagic_fever_orthonairovirus Crimean-Congo hemorrhagic fever orthonairovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DC5 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[8dc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthonairovirus_haemorrhagiae Orthonairovirus haemorrhagiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DC5 FirstGlance]. <br>
 </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.21&#8491;</td></tr>
 <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
@@ Line 9: / Line 9: @@
 </table>
 == Function ==
-[https://www.uniprot.org/uniprot/A0A7T6Y557_9VIRU A0A7T6Y557_9VIRU] Glycoprotein C and glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion.[PIRNR:PIRNR003962]
+[https://www.uniprot.org/uniprot/A0A7T6Y557_9VIRU A0A7T6Y557_9VIRU] Binds to host cell surface receptor LDLR and mediates fusion between viral and cellular membranes. Attachment to receptor induces virion internalization predominantly through clathrin-dependent endocytosis. Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Exposure of the glycoprotein spikes to potassium is necessary for the conformational change leading to fusion.[PIRNR:PIRNR003962]  Plays a role in virion attachment to host receptor. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Glycoprotein N probably locks the Gn-Gc complex in a prefusion state.[PIRNR:PIRNR003962]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 26: / Line 26: @@
 __TOC__
 </StructureSection>
-[[Category: Crimean-Congo hemorrhagic fever orthonairovirus]]
 [[Category: Large Structures]]
+[[Category: Orthonairovirus haemorrhagiae]]
 [[Category: Bergeron E]]
 [[Category: Durie IA]]
 [[Category: McGuire J]]
 [[Category: Pegan SD]]