Journal:Protein Science:4: Difference between revisions

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Joel L. Sussman (talk | contribs)
ConfirmAccount, Editor, Mutation, Print3D, Tester, Bureaucrats, journal
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Joel L. Sussman (talk | contribs)
ConfirmAccount, Editor, Mutation, Print3D, Tester, Bureaucrats, journal
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</jmol> between these two states.
</jmol> between these two states.


The 4A/3B motif’s metal-binding strength is ~10 kcal/mol weaker compared to motifs with multiple anionic residues not surrounded by cationic residues. This flexibility without conformational change suggests the motif may act as a metal ion reservoir, potentially regulating metal concentrations or adapting thermal stability. Similar motifs were found in other proteins, indicating a broader functional role beyond ''Tc''AChE.
The 4A/3B motif’s metal-binding strength is ~10 kcal/mol weaker than motifs with multiple anionic residues '''not''' surrounded by cationic residues. This flexibility without conformational change suggests the motif may act as a metal ion reservoir, potentially regulating metal concentrations or adapting thermal stability. Similar motifs were found in other proteins, indicating a broader functional role beyond ''Tc''AChE.


<b>References</b>
<b>References</b>
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