2bka: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 8: Line 8:
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bka OCA], [https://pdbe.org/2bka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bka RCSB], [https://www.ebi.ac.uk/pdbsum/2bka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bka ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bka FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bka OCA], [https://pdbe.org/2bka PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bka RCSB], [https://www.ebi.ac.uk/pdbsum/2bka PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bka ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HTAI2_HUMAN HTAI2_HUMAN] Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.<ref>PMID:10611237</ref> <ref>PMID:11313954</ref> <ref>PMID:15282309</ref> <ref>PMID:9174052</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 15: Line 13:
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/2bka_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bk/2bka_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
Retrieved from "https://proteopedia.org/2bka"