1udd: Difference between revisions
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'''TenA homologue protein from P.horikoshii OT3''' | '''TenA homologue protein from P.horikoshii OT3''' | ||
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[[Category: Watanabe, N.]] | [[Category: Watanabe, N.]] | ||
[[Category: Yao, M.]] | [[Category: Yao, M.]] | ||
[[Category: | [[Category: Helix-bundle]] | ||
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Revision as of 08:04, 3 May 2008
TenA homologue protein from P.horikoshii OT3
Overview
The crystal structure of the Bacillus subtilis TenA-homologue protein PH1161 from the hyperthermophilic archaebacterium Pyrococcus horikoshii was determined. TenA is known to belong to a new family of activators that stimulate the production of extracellular proteases in B. subtilis. A sequence-similarity search revealed that TenA-homologue proteins are widespread in bacteria and archaea, suggesting that this family of proteins plays an essential role in these organisms. In the present study, the first three-dimensional structure of a member of the TenA family of proteins was determined, unexpectedly revealing that the protein has a fold identical to that of haem oxygenase-1. Analysis has also shown that the protein has a unique ligand-binding pocket. Electron density of a bound ligand molecule was observed in this pocket. These results provide a valuable insight into the functional understanding of the TenA family of proteins.
About this Structure
1UDD is a Single protein structure of sequence from Pyrococcus horikoshii. Full crystallographic information is available from OCA.
Reference
Structure analysis of PH1161 protein, a transcriptional activator TenA homologue from the hyperthermophilic archaeon Pyrococcus horikoshii., Itou H, Yao M, Watanabe N, Tanaka I, Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1094-100. Epub 2004, May 21. PMID:15159569 Page seeded by OCA on Sat May 3 11:04:07 2008
