2f3e: Difference between revisions

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<StructureSection load='2f3e' size='340' side='right'caption='[[2f3e]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
<StructureSection load='2f3e' size='340' side='right'caption='[[2f3e]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2f3e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3E FirstGlance]. <br>
<table><tr><td colspan='2'>[[2f3e]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F3E FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AXQ:{(E)-(3R,6S,9R)-3-[(1S,3R)-3-((S)-1+-BUTYLCARBAMOYL-2-METHYL-PROPYLCARB+AMOYL)-1-HYDROXY-BUTYL]-6-METHYL-5,+8-DIOXO-1,11-DITHIA-4,7-DIAZA-CYCLO+PENTADEC-13-EN-9-YL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>AXQ</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2f3f|2f3f]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AXQ:{(E)-(3R,6S,9R)-3-[(1S,3R)-3-((S)-1+-BUTYLCARBAMOYL-2-METHYL-PROPYLCARB+AMOYL)-1-HYDROXY-BUTYL]-6-METHYL-5,+8-DIOXO-1,11-DITHIA-4,7-DIAZA-CYCLO+PENTADEC-13-EN-9-YL}-CARBAMIC+ACID+TERT-BUTYL+ESTER'>AXQ</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3e OCA], [https://pdbe.org/2f3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3e RCSB], [https://www.ebi.ac.uk/pdbsum/2f3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f3e OCA], [https://pdbe.org/2f3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f3e RCSB], [https://www.ebi.ac.uk/pdbsum/2f3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f3e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> 
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f3e_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f3/2f3e_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Memapsin 2]]
[[Category: Rondeau J-M]]
[[Category: Rondeau, J M]]
[[Category: Alzheimer's disease]]
[[Category: Aspartic protease]]
[[Category: Beta-secretase]]
[[Category: Hydrolase]]
[[Category: Macrocyclic peptidomimetic inhibitor]]
[[Category: Memapsin2]]
Retrieved from "https://proteopedia.org/2f3e"