2iw3: Difference between revisions
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<StructureSection load='2iw3' size='340' side='right'caption='[[2iw3]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='2iw3' size='340' side='right'caption='[[2iw3]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2iw3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2iw3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IW3 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iw3 OCA], [https://pdbe.org/2iw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2iw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iw3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iw3 OCA], [https://pdbe.org/2iw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iw3 RCSB], [https://www.ebi.ac.uk/pdbsum/2iw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iw3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/EF3A_YEAST EF3A_YEAST] Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis. Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied.<ref>PMID:6456269</ref> <ref>PMID:7657623</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iw3_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/2iw3_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Anand | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Andersen | [[Category: Anand M]] | ||
[[Category: Andersen | [[Category: Andersen CBF]] | ||
[[Category: Balar | [[Category: Andersen GR]] | ||
[[Category: Becker | [[Category: Balar B]] | ||
[[Category: Beckmann | [[Category: Becker T]] | ||
[[Category: Blau | [[Category: Beckmann R]] | ||
[[Category: Boesen | [[Category: Blau M]] | ||
[[Category: Halic | [[Category: Boesen T]] | ||
[[Category: Kinzy | [[Category: Halic M]] | ||
[[Category: Mielke | [[Category: Kinzy TG]] | ||
[[Category: Pedersen | [[Category: Mielke T]] | ||
[[Category: Spahn | [[Category: Pedersen JS]] | ||
[[Category: Spahn CMT]] | |||
Latest revision as of 01:04, 21 November 2024
Elongation Factor 3 in complex with ADP
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