2kk9: Difference between revisions

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==Anti-group A streptococcal vaccine epitope: structure, stability and its ability to interact with HLA class II molecules==
==Anti-group A streptococcal vaccine epitope: structure, stability and its ability to interact with HLA class II molecules==
<StructureSection load='2kk9' size='340' side='right'caption='[[2kk9]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2kk9' size='340' side='right'caption='[[2kk9]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kk9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KK9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kk9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M5 Streptococcus pyogenes serotype M5]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KK9 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kk9 OCA], [https://pdbe.org/2kk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kk9 RCSB], [https://www.ebi.ac.uk/pdbsum/2kk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kk9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kk9 OCA], [https://pdbe.org/2kk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kk9 RCSB], [https://www.ebi.ac.uk/pdbsum/2kk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kk9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/M5_STRP5 M5_STRP5]] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/2kk9_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kk/2kk9_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Alba, M P]]
[[Category: Streptococcus pyogenes serotype M5]]
[[Category: Guilherme, L]]
[[Category: Alba MP]]
[[Category: Kalil, J]]
[[Category: Guilherme L]]
[[Category: Patarroyo, M E]]
[[Category: Kalil J]]
[[Category: Antimicrobial protein]]
[[Category: Patarroyo ME]]
[[Category: Cell wall]]
[[Category: M5 protein]]
[[Category: Peptidoglycan-anchor]]
[[Category: Phagocytosis]]
[[Category: S. pyogene]]
[[Category: Secreted]]
[[Category: Synthetic peptide vaccine]]
[[Category: Unknown function]]
[[Category: Virulence]]
Retrieved from "https://proteopedia.org/2kk9"