3l0r: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 9: | Line 9: | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ | [https://www.uniprot.org/uniprot/CYS2_ORNMO CYS2_ORNMO] Inhibitor of cysteine proteinases with broad specificity for mammalian cathepsins, including endopeptidases (cathepsins L and S) and exopeptidases (cathepsins B, C and H) (PubMed:17132111, PubMed:20545626). Also inhibits endogenous cathepsin B-like and cathepsin C-like proteinases (PubMed:17132111). Does not inhibit human legumain (PubMed:20545626). May mimic specific host-derived cystatin(s) to interfere with its/their function in controlling cathepsin-mediated proteolysis (PubMed:20545626). Affects the function of antigen-presenting mouse dendritic cells by reducing the production of the pro-inflammatory cytokines TNF and interleukin-12, and proliferation of antigen-specific CD4+ T-cells, suggesting it may suppress the host adaptive immune response (PubMed:20545626). It is noteworthy that immunization of mice with this protein reduces O.moubata survival in infestation experiments (PubMed:20545626).<ref>PMID:17132111</ref> <ref>PMID:20545626</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 15: | Line 15: | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/3l0r_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/3l0r_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
