3tul: Difference between revisions

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<StructureSection load='3tul' size='340' side='right'caption='[[3tul]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
<StructureSection load='3tul' size='340' side='right'caption='[[3tul]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tul]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TUL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tul]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TUL FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.793&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u0c|3u0c]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">sipB, sspB, STM2885 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tul OCA], [https://pdbe.org/3tul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tul RCSB], [https://www.ebi.ac.uk/pdbsum/3tul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tul ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tul OCA], [https://pdbe.org/3tul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tul RCSB], [https://www.ebi.ac.uk/pdbsum/3tul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tul ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/SIPB_SALTY SIPB_SALTY]] Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE.<ref>PMID:10051653</ref> <ref>PMID:14662750</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus typhimurium loeffler 1892]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Barta, M L]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
[[Category: Dickenson, N E]]
[[Category: Barta ML]]
[[Category: Geisbrecht, B V]]
[[Category: Dickenson NE]]
[[Category: Keightley, J A]]
[[Category: Geisbrecht BV]]
[[Category: Patel, M]]
[[Category: Keightley JA]]
[[Category: Picking, W D]]
[[Category: Patel M]]
[[Category: Picking, W L]]
[[Category: Picking WD]]
[[Category: Cell invasion]]
[[Category: Picking WL]]
[[Category: Coiled-coil]]
[[Category: Translocator]]
[[Category: Type three secretion system]]
[[Category: Virulence]]
Retrieved from "https://proteopedia.org/3tul"