3uf5: Difference between revisions

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<StructureSection load='3uf5' size='340' side='right'caption='[[3uf5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='3uf5' size='340' side='right'caption='[[3uf5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3uf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UF5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3uf5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UF5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UF5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3ejj|3ejj]], [[3uez|3uez]], [[3uf2|3uf2]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Csf1, Csfm ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uf5 OCA], [https://pdbe.org/3uf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uf5 RCSB], [https://www.ebi.ac.uk/pdbsum/3uf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uf5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uf5 OCA], [https://pdbe.org/3uf5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uf5 RCSB], [https://www.ebi.ac.uk/pdbsum/3uf5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uf5 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Note=A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.<ref>PMID:2188141</ref> 
== Function ==
[[https://www.uniprot.org/uniprot/CSF1_MOUSE CSF1_MOUSE]] Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Bekaert, A]]
[[Category: Bekaert A]]
[[Category: Bracke, N]]
[[Category: Bracke N]]
[[Category: Elegheert, J]]
[[Category: Elegheert J]]
[[Category: Savvides, S N]]
[[Category: Savvides SN]]
[[Category: Cytokine]]
[[Category: Four-helix bundle]]
[[Category: Hematopoietic cytokine]]
[[Category: Rtkiii]]

Latest revision as of 02:30, 21 November 2024

Crystal structure of the mouse Colony-Stimulating Factor 1 (mCSF-1) cytokine

3uf5, resolution 2.80Å

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