4as3: Difference between revisions
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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/PCHP_PSEAE PCHP_PSEAE] Catalyzes the hydrolysis of phosphorylcholine (PCho) to produce choline and inorganic phosphate (PubMed: | [https://www.uniprot.org/uniprot/PCHP_PSEAE PCHP_PSEAE] Catalyzes the hydrolysis of phosphorylcholine (PCho) to produce choline and inorganic phosphate (PubMed:10387109, PubMed:15886911, PubMed:17106798, PubMed:2116592). Can also hydrolyze phosphorylethanolamine and the nonphysiological substrate p-nitrophenylphosphate (pNPP) (PubMed:10387109, PubMed:15886911, PubMed:17106798, PubMed:2116592). Shows higher affinity and catalytic efficiency with phosphorylcholine as substrate (PubMed:2116592).<ref>PMID:10387109</ref> <ref>PMID:15886911</ref> <ref>PMID:17106798</ref> <ref>PMID:2116592</ref> Is probably involved in virulence (PubMed:19103776, Ref.3). The bacteria may break down various host compounds or host cell membranes through the coordinated action of phospholipase C and phosphocholine phosphatase. The final consequence of the action of these enzymes is an increase of the free choline concentration, which may promote the pathogenicity of P.aeruginosa (Ref.3).<ref>PMID:19103776</ref> <ref>PMID:15886911</ref> | ||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
