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==TesA a major thioesterase from Mycobacterium tuberculosis==
==TesA a major thioesterase from Mycobacterium tuberculosis==
<StructureSection load='6fvj' size='340' side='right' caption='[[6fvj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='6fvj' size='340' side='right'caption='[[6fvj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fvj]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FVJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FVJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fvj]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FVJ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=E9H:hexadecyl+dihydrogen+phosphate'>E9H</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mbtB_1, mbtB_2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=E9H:hexadecyl+dihydrogen+phosphate'>E9H</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fvj OCA], [http://pdbe.org/6fvj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fvj RCSB], [http://www.ebi.ac.uk/pdbsum/6fvj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fvj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fvj OCA], [https://pdbe.org/6fvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fvj RCSB], [https://www.ebi.ac.uk/pdbsum/6fvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fvj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TESA_MYCTU TESA_MYCTU] Involved in the synthesis of both phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs), which are structurally related lipids non-covalently bound to the outer cell wall layer of M.tuberculosis and are important virulence factors (PubMed:30292819). In vitro, TesA has both thioesterase and esterase activities (PubMed:30292819, PubMed:31388991). Exhibits thioesterase activity on acyl-CoA derivatives such as palmitoyl-CoA and decanoyl-CoA (PubMed:30292819, PubMed:31388991). Also displays hydrolytic activity on ester substrates, being more active on pNP esters with short carbon chain lengths (C2-C5) than with those bearing medium and long carbon chain lengths (C8-C18) (PubMed:30292819).<ref>PMID:30292819</ref> <ref>PMID:31388991</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6fvj" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fvj" style="background-color:#fffaf0;"></div>
==See Also==
*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cambillau, C]]
[[Category: Large Structures]]
[[Category: Canaan, S]]
[[Category: Nguyen, V S]]
[[Category: Hydrolase]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Tesa]]
[[Category: Cambillau C]]
[[Category: Thioesterase]]
[[Category: Canaan S]]
[[Category: Nguyen VS]]
Retrieved from "https://proteopedia.org/6fvj"