6pv7: Difference between revisions

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<SX load='6pv7' size='340' side='right' viewer='molstar' caption='[[6pv7]], [[Resolution|resolution]] 3.34&Aring;' scene=''>
<SX load='6pv7' size='340' side='right' viewer='molstar' caption='[[6pv7]], [[Resolution|resolution]] 3.34&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6pv7]] is a 9 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PV7 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6PV7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6pv7]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_O11 Escherichia coli O11], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PV7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6PV7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=DD9:NONANE'>DD9</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.34&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRNA3, NACHRA3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CHRNB4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=DD9:NONANE'>DD9</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NCT:(S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE'>NCT</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6pv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pv7 OCA], [http://pdbe.org/6pv7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6pv7 RCSB], [http://www.ebi.ac.uk/pdbsum/6pv7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6pv7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6pv7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pv7 OCA], [https://pdbe.org/6pv7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6pv7 RCSB], [https://www.ebi.ac.uk/pdbsum/6pv7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6pv7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/ACHB4_HUMAN ACHB4_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. [[http://www.uniprot.org/uniprot/ACHA3_HUMAN ACHA3_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6pv7" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6pv7" style="background-color:#fffaf0;"></div>
==See Also==
*[[Acetyl choline receptor 3D structures|Acetyl choline receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</SX>
</SX>
[[Category: Human]]
[[Category: Escherichia coli O11]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Cabuco, R]]
[[Category: Cabuco R]]
[[Category: Gharpure, A]]
[[Category: Gharpure A]]
[[Category: Hibbs, R E]]
[[Category: Hibbs RE]]
[[Category: Howard, R J]]
[[Category: Howard RJ]]
[[Category: Lindahl, E]]
[[Category: Lindahl E]]
[[Category: Noviello, C M]]
[[Category: Noviello CM]]
[[Category: Teng, J]]
[[Category: Teng J]]
[[Category: Walsh, R M]]
[[Category: Walsh RM]]
[[Category: Zaveri, N T]]
[[Category: Zaveri NT]]
[[Category: Zhuang, Y]]
[[Category: Zhuang Y]]
[[Category: Cys-loop receptor]]
[[Category: Ligand-gated ion channel]]
[[Category: Membrane protein]]
[[Category: Nicotinic acetylcholine receptor]]

Latest revision as of 05:35, 21 November 2024

Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine

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