6qu9: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qu9 OCA], [https://pdbe.org/6qu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qu9 RCSB], [https://www.ebi.ac.uk/pdbsum/6qu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qu9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6qu9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qu9 OCA], [https://pdbe.org/6qu9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6qu9 RCSB], [https://www.ebi.ac.uk/pdbsum/6qu9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6qu9 ProSAT]</span></td></tr> | ||
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== Publication Abstract from PubMed == | |||
The serpinopathies are among a diverse set of conformational diseases that involve the aberrant self-association of proteins into ordered aggregates. alpha1-Antitrypsin deficiency is the archetypal serpinopathy and results from the formation and deposition of mutant forms of alpha1-antitrypsin as "polymer" chains in liver tissue. No detailed structural analysis has been performed of this material. Moreover, there is little information on the relevance of well-studied artificially induced polymers to these disease-associated molecules. We have isolated polymers from the liver tissue of Z alpha1-antitrypsin homozygotes (E342K) who have undergone transplantation, labeled them using a Fab fragment, and performed single-particle analysis of negative-stain electron micrographs. The data show structural equivalence between heat-induced and ex vivo polymers and that the intersubunit linkage is best explained by a carboxyl-terminal domain swap between molecules of alpha1-antitrypsin. | |||
The structural basis for Z alpha1-antitrypsin polymerization in the liver.,Faull SV, Elliston ELK, Gooptu B, Jagger AM, Aldobiyan I, Redzej A, Badaoui M, Heyer-Chauhan N, Rashid ST, Reynolds GM, Adams DH, Miranda E, Orlova EV, Irving JA, Lomas DA Sci Adv. 2020 Oct 21;6(43). pii: 6/43/eabc1370. doi: 10.1126/sciadv.abc1370., Print 2020 Oct. PMID:33087346<ref>PMID:33087346</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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<div class="pdbe-citations 6qu9" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[Antibody 3D structures|Antibody 3D structures]] | *[[Antibody 3D structures|Antibody 3D structures]] | ||
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | *[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]] | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
