7et3: Difference between revisions

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====
==C5 portal vertex in the enveloped virion capsid==
<StructureSection load='7et3' size='340' side='right'caption='[[7et3]]' scene=''>
<StructureSection load='7et3' size='340' side='right'caption='[[7et3]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
<table><tr><td colspan='2'>[[7et3]] is a 23 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_betaherpesvirus_5 Human betaherpesvirus 5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ET3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ET3 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7et3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7et3 OCA], [https://pdbe.org/7et3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7et3 RCSB], [https://www.ebi.ac.uk/pdbsum/7et3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7et3 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7et3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7et3 OCA], [https://pdbe.org/7et3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7et3 RCSB], [https://www.ebi.ac.uk/pdbsum/7et3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7et3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SCP_HCMVA SCP_HCMVA] Participates in the assembly of the infectious particles by decorating the outer surface of the capsid shell and thus forming a layer between the capsid and the tegument. Complexes composed of the major capsid protein and small capsomere-interacting protein/SCP assemble together in the host cytoplasm and are translocated to the nucleus, where they accumulate and participate in capsid assembly.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
How the human cytomegalovirus (HCMV) genome-the largest among human herpesviruses-is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry-mismatched portal and the capsid vertex-specific components (CVSCs) of HCMV. The 5-fold symmetric 10-helix anchor-uncommon among known portals-contacts the portal-encircling DNA, which is presumed to squeeze the portal as the genome packaging proceeds. We surmise that the 10-helix anchor dampens this action to delay the portal reaching a "head-full" packaging state, thus facilitating the large genome to be packaged. The 6-fold symmetric turret, latched via a coiled coil to a helix from a major capsid protein, supports the portal to retain the packaged genome. CVSCs at the penton vertices-presumed to increase inner capsid pressure-display a low stoichiometry, which would aid genome retention. We also demonstrate that the portal and capsid undergo conformational changes to facilitate genome ejection after viral cell entry.
Structural basis for genome packaging, retention, and ejection in human cytomegalovirus.,Li Z, Pang J, Dong L, Yu X Nat Commun. 2021 Jul 27;12(1):4538. doi: 10.1038/s41467-021-24820-3. PMID:34315863<ref>PMID:34315863</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7et3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human betaherpesvirus 5]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Z-disk]]
[[Category: Li Z]]
[[Category: Yu X]]
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