2lld: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2lld]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lucilia_sericata Lucilia sericata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LLD FirstGlance]. <br>
<table><tr><td colspan='2'>[[2lld]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lucilia_sericata Lucilia sericata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LLD FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lld OCA], [https://pdbe.org/2lld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lld RCSB], [https://www.ebi.ac.uk/pdbsum/2lld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lld ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lld OCA], [https://pdbe.org/2lld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lld RCSB], [https://www.ebi.ac.uk/pdbsum/2lld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lld ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DEFLU_LUCSE DEFLU_LUCSE] Shows strong antibacterial activity against numerous Gram-positive bacteria. It selectively inhibits peptidoglycan biosynthesis through complex formation with the cell wall precursor lipid II (1:1 molar ratio) thus inhibiting cell wall synthesis (PubMed:20508130). Shows antibacterial activity against the Gram-positive bacteria M.luteus, E.fecalis (MIC=32 mg/L), S.aureus (MIC=16 mg/L), S.carnosus (MIC=2 mg/L), S.pneumoniae (MIC=2 mg/L) and S.pyogenes (MIC=2 mg/L) and against a number of methicillin-resistant S.aureus and glycopeptide-intermediate S.aureus isolates (PubMed:20542901, PubMed:19921400, PubMed:21560219). Does not show antibacterial activity against Gram-negative bacteria or antifungal activity against C.utilis (PubMed:20542901). Shows slight antifungal activity against C.albicans (PubMed:21560219).<ref>PMID:19921400</ref> <ref>PMID:20542901</ref> <ref>PMID:21560219</ref> <ref>PMID:20508130</ref>
== References ==
<references/>
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</StructureSection>
</StructureSection>
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