8xl9: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
Line 1: Line 1:
'''Unreleased structure'''


The entry 8xl9 is ON HOLD  until Paper Publication
==Structure of human pyruvate carboxylase==
 
<StructureSection load='8xl9' size='340' side='right'caption='[[8xl9]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
Authors: Zhou, F.Y., Zhang, Y.Y., Zhou, Q., Hu, Q.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8xl9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XL9 FirstGlance]. <br>
Description: Structure of human pyruvate carboxylase
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.61&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTN:BIOTIN'>BTN</scene></td></tr>
[[Category: Zhou, F.Y]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xl9 OCA], [https://pdbe.org/8xl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xl9 RCSB], [https://www.ebi.ac.uk/pdbsum/8xl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xl9 ProSAT]</span></td></tr>
[[Category: Zhou, Q]]
</table>
[[Category: Hu, Q]]
== Disease ==
[[Category: Zhang, Y.Y]]
[https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Defects in PC are the cause of pyruvate carboxylase deficiency (PC deficiency) [MIM:[https://omim.org/entry/266150 266150]. PC deficiency leads to lactic acidosis, mental retardation and death. It occurs in three forms: mild or type A, severe neonatal or type B, and a very mild lacticacidemia.
== Function ==
[https://www.uniprot.org/uniprot/PYC_HUMAN PYC_HUMAN] Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Hu Q]]
[[Category: Zhang YY]]
[[Category: Zhou FY]]
[[Category: Zhou Q]]
Retrieved from "https://proteopedia.org/8xl9"