9ay9: Difference between revisions
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==Co-crystal structure of human PRMT9 in complex with MRK-990 inhibitor== | |||
<StructureSection load='9ay9' size='340' side='right'caption='[[9ay9]], [[Resolution|resolution]] 2.22Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ay9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9AY9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9AY9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.22Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AHM:(2~{R},3~{R},4~{S},5~{S})-2-(4-azanyl-5-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-[4-[(2-~{tert}-butylpyridin-3-yl)methylamino]butylsulfanylmethyl]oxolane-3,4-diol'>A1AHM</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ay9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ay9 OCA], [https://pdbe.org/9ay9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ay9 RCSB], [https://www.ebi.ac.uk/pdbsum/9ay9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ay9 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/ANM9_HUMAN ANM9_HUMAN] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344).<ref>PMID:25737013</ref> <ref>PMID:25979344</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arrowsmith CH]] | ||
[[Category: | [[Category: Brown PJ]] | ||
[[Category: | [[Category: Dong A]] | ||
[[Category: | [[Category: Edwards AM]] | ||
[[Category: | [[Category: Fischer C]] | ||
[[Category: | [[Category: Gao YD]] | ||
[[Category: | [[Category: Halabelian L]] | ||
[[Category: Hicks J]] | |||
[[Category: Hutchinson A]] | |||
[[Category: Li Y]] | |||
[[Category: Nicholson B]] | |||
[[Category: Schneider S]] | |||
[[Category: Seitova A]] | |||
[[Category: Siliphaivanh P]] | |||
[[Category: Sloman D]] | |||
[[Category: Zeng H]] | |||
Latest revision as of 06:19, 4 December 2024
Co-crystal structure of human PRMT9 in complex with MRK-990 inhibitor
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