8yw2: Difference between revisions
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==Semliki Forest virus viron in complex with VLDLR== | |||
<StructureSection load='8yw2' size='340' side='right'caption='[[8yw2]], [[Resolution|resolution]] 3.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8yw2]] is a 65 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Semliki_Forest_virus_4 Semliki Forest virus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YW2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yw2 OCA], [https://pdbe.org/8yw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yw2 RCSB], [https://www.ebi.ac.uk/pdbsum/8yw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yw2 ProSAT]</span></td></tr> | ||
[[Category: Yang | </table> | ||
[[Category: | == Disease == | ||
[https://www.uniprot.org/uniprot/VLDLR_HUMAN VLDLR_HUMAN] Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1) [MIM:[https://omim.org/entry/224050 224050]; also known as dysequilibrium syndrome (DES) or non-progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures.<ref>PMID:16080122</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VLDLR_HUMAN VLDLR_HUMAN] Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Semliki Forest virus 4]] | |||
[[Category: Wang J]] | |||
[[Category: Yang D]] | |||
[[Category: Zheng T]] | |||
Latest revision as of 20:01, 11 December 2024
Semliki Forest virus viron in complex with VLDLR
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