Journal:Protein Science:2: Difference between revisions
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<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
Crystal structure of ''Tc''AChE <scene name='72/725874/Cv/ | Crystal structure of ''Tc''AChE <scene name='72/725874/Cv/40'>shows its two subdomains</scene> (<font color='purple'><b>residues 4-305, purple</b></font>, and <font color='red'><b>residues 306-535, red</b></font>). The <scene name='72/725874/Cv/29'>entrance to the active-site gorge</scene> located between the two sub-domains. There are several of the conserved aromatic residues: <scene name='72/725874/Cv/30'>Trp279</scene>, in the peripheral anionic site (PAS) at the top of the gorge; <scene name='72/725874/Cv/31'>Tyr121</scene>, mid-way down the gorge, and <scene name='72/725874/Cv/32'>Trp84</scene>, the principal element of the catalytic ‘anionic’ sub-site (CAS), near the bottom. CAS involves the <scene name='72/725874/Cv/33'>catalytic triad Ser200, His440, and Glu327</scene>. <span style="color:yellow;background-color:black;font-weight:bold;">The carbon atoms of these conserved residues colored yellow</span>. | ||
Structure-based drug design utilizes experimental 3D apo-protein or complex structures that are usually retrieved from the PDB. Over 57% of the crystallographic PDB entries were obtained with polyethyleneglycols (PEGs) as precipitant and/or as cryoprotectant, but fewer than 6% of | Structure-based drug design utilizes experimental 3D apo-protein or complex structures that are usually retrieved from the PDB. Over 57% of the crystallographic PDB entries were obtained with polyethyleneglycols (PEGs) as precipitant and/or as cryoprotectant, but fewer than 6% of | ||
This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For additional details please see I3DC.
