Semaglutide: Difference between revisions

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==Synthesis==
==Synthesis==
Semaglutide is made by Novo Nordisc, and the details are proprietary. The product is semisynthetic, with the bulk of the peptide made in recombinant yeast<ref name="euro">Committee for Medicinal Products for Human use (CHMP). European Medicines Agency (EMA). (2018).   
Semaglutide is made by Novo Nordisk, and the details are proprietary. The product is semisynthetic, with the bulk of the peptide made in recombinant yeast<ref name="euro">Committee for Medicinal Products for Human use (CHMP). European Medicines Agency (EMA). (2018).   


https://www.ema.europa.eu/en/documents/assessment-report/ozempic-epar-public-assessment-report_en.pdf</ref> and the fatty acid and the first two amino acids attached afterwards. Because the second lysine of GLP-1 is replaced by an arginine in semaglutide, the fatty acid is attached to a single lysine, simplifying the coupling between peptide and linker-attached fatty acid.
https://www.ema.europa.eu/en/documents/assessment-report/ozempic-epar-public-assessment-report_en.pdf</ref> and the fatty acid and the first two amino acids attached afterwards. Because the second lysine of GLP-1 is replaced by an arginine in semaglutide, the fatty acid is attached to a single lysine, simplifying the coupling between peptide and linker-attached fatty acid.
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