Semaglutide: Difference between revisions
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Semaglutide was discovered <ref>PMID:26308095</ref> in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the [[GLP-1]] hormone, contains two amino acid sequence changes and a covalently attached lipid. | Semaglutide was discovered <ref>PMID:26308095</ref> in an effort to increase the lifetime of a once-a-day medication called Liraglutide. It is derived from the [[GLP-1]] hormone, contains two amino acid sequence changes and a covalently attached lipid. | ||
<StructureSection load=' | <StructureSection load='' size='340' side='right' caption='' scene='10/1062575/Semaglutide_and_receptor/2'> | ||
==Structure and binding to GLP-1R== | ==Structure and binding to GLP-1R== | ||
The primary structure of GLP-1 and of semaglutide are shown below. Semaglutide has a non-canonical amino acid in position 8 (corresponding to the second amino acid in the mature 7-37 peptide hormone). A fatty acid is attached is attached to the single lysine in semaglutide via a linker. | The primary structure of GLP-1 and of semaglutide are shown below. Semaglutide has a non-canonical amino acid in position 8 (corresponding to the second amino acid in the mature 7-37 peptide hormone). A fatty acid is attached is attached to the single lysine in semaglutide via a linker. | ||
