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| </table> | | </table> |
| == Function == | | == Function == |
| [https://www.uniprot.org/uniprot/A0A059VJE6_9ALPC A0A059VJE6_9ALPC] Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.[ARBA:ARBA00002928] Nsp9 is a ssRNA-binding protein.[ARBA:ARBA00003140] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.[ARBA:ARBA00025562] | | [https://www.uniprot.org/uniprot/A0A059VJE6_9ALPC A0A059VJE6_9ALPC] |
| | |
| | ==See Also== |
| | *[[3D structures of ubiquitin|3D structures of ubiquitin]] |
| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
