9iya: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9iya is ~~ON HOLD until Paper Publication~~

==Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9iya]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IYA OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9IYA FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L3E:4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{N}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{H}-quinoline-3-carboxamide'>A1L3E</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9iya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9iya OCA], [https://pdbe.org/9iya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9iya RCSB], [https://www.ebi.ac.uk/pdbsum/9iya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9iya ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/GPR55_HUMAN GPR55_HUMAN] G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation (PubMed:36142844). In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation (PubMed:37544935).<ref>PMID:19805329</ref> <ref>PMID:36142844</ref> <ref>PMID:36523570</ref> <ref>PMID:37544935</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Chang H]]

[[Category: Cherezov V]]

[[Category: Hua T]]

[[Category: Li XT]]

[[Category: Liu ZJ]]

[[Category: Shen L]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9iya is ON HOLD  until Paper Publication
+==Cryo-EM structure of GPR55-Fab-Nb-ONO-9710531 complex==
+<StructureSection load='9iya' size='340' side='right'caption='[[9iya]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9iya]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9IYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9IYA FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1L3E:4-(3-bromanyl-5-ethoxy-4-oxidanyl-phenyl)-~{N}-(2-methoxyphenyl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1~{H}-quinoline-3-carboxamide'>A1L3E</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9iya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9iya OCA], [https://pdbe.org/9iya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9iya RCSB], [https://www.ebi.ac.uk/pdbsum/9iya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9iya ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GPR55_HUMAN GPR55_HUMAN] G-protein coupled receptor that binds to several ligands including 2-arachidonoyl lysophosphatidylinositol or lysophosphatidylglucoside with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways (PubMed:36142844, PubMed:36523570, PubMed:37544935). Induces the Ca(2+) release from intracellular stores via ERK, the heterotrimeric G protein GNA13 and RHOA leading to morphological changes including cell rounding and stress fiber formation (PubMed:36142844). In macrophages, acts downstream of lysophosphatidylglucoside to inhibit the translocation of the phospholipid-transporting ABCA1 to plasma membrane and subsequent cholesterol efflux leading to lipid accumulation and foam cell formation (PubMed:37544935).<ref>PMID:19805329</ref> <ref>PMID:36142844</ref> <ref>PMID:36523570</ref> <ref>PMID:37544935</ref> [https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chang H]]
+[[Category: Cherezov V]]
+[[Category: Hua T]]
+[[Category: Li XT]]
+[[Category: Liu ZJ]]
+[[Category: Shen L]]