Cytochrome P450

spinqualitylabelsall models Cytochrome P450 CypC2 with heme C complex with warfarin (PDB entry 1og5) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cytochrome P450 (P450) or cytochrome P450 monooxygenase catalyzes the oxidation of organic substances like lipids. The P450 contains a heme cofactor. The protein is numbered by its gene. P450 CYP121 is called mycocyclosin synthase. P450cam, also known as camphor 5-monooxygenase, catalyzes the hydroxylation of camphor. P450nor is a Nitric Oxide Reductase P450. P450epoK converts epothilone D to epothilone B. P450cin monooxygenates 1,8-cineole which is similar to camphor. Bifunctional P450/NADPH P450 reductase (P450 BM3) is a fatty acid monooxygenase. P450 3A4 see CYP3A4. P450 19 family see Aromatase. P450 17A1 see Human steroidogenic cytochrome P450 17A1 with inhibitor abiraterone See also Hemeproteins. Additional details on cytochrome P450 interactions with drugs see Drug Metabolism by CYP450 Enzymes Montelukast - anti rhinitis Noxafil - antifungal drug which binds to CYP51. Cobicistat - anti HIV/AIDS drug which binds to CYP3A4. Cytochrome P450 inhibitors Structural highlights The heme moiety is stabilized by several side chains. The heme iron is pentacoordinated with Cys as one ligand. 3D Structures of Cytochrome P450 Cytochrome P450 3D structures

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