9kx8: Difference between revisions

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'''Unreleased structure'''


The entry 9kx8 is ON HOLD
==Mistletoe Lectin I from Viscum album complexed with epimer form of lactose==
 
<StructureSection load='9kx8' size='340' side='right'caption='[[9kx8]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
Authors: Saeed, A., Betzel, C., Brognaro, H., Rajaiah Prabhu, P., Alves Franca, B., Khaliq, B., Akrem, A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9kx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9KX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9KX8 FirstGlance]. <br>
Description: Mistletoe Lectin I from Viscum album complexed with epimer form of lactose
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZCD:alpha-D-idopyranose'>ZCD</scene></td></tr>
[[Category: Khaliq, B]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9kx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9kx8 OCA], [https://pdbe.org/9kx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9kx8 RCSB], [https://www.ebi.ac.uk/pdbsum/9kx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9kx8 ProSAT]</span></td></tr>
[[Category: Brognaro, H]]
</table>
[[Category: Alves Franca, B]]
== Function ==
[[Category: Rajaiah Prabhu, P]]
[https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref>
[[Category: Saeed, A]]
== References ==
[[Category: Betzel, C]]
<references/>
[[Category: Akrem, A]]
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Viscum album]]
[[Category: Akrem A]]
[[Category: Alves Franca B]]
[[Category: Betzel C]]
[[Category: Brognaro H]]
[[Category: Khaliq B]]
[[Category: Mehmood S]]
[[Category: Rajaiah Prabhu P]]
[[Category: Saeed A]]
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