CD59

spinqualitylabelsall models Structure of human CD59 extracellular domain (green) complex with intermedilysin (cyan) (PDB entry 4bik) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function CD59 (Cluster of Differentiation 59) is a protein which attaches to host cells via a GPI anchor. CD59 can prevent the formation of complement membrane attack complex via binding to complement C8 or C9. Relevance HIV, vaccinia and cytomegalovirus incorporate human CD59 into their envelope thus preventing their lysis by complement. Disease Mutations in CD59 causes disease involving thrombosis. Structural highlights Human CD59 extracellular domain complex with intermedilysin .

3D structures of CD59

Updated on 20-January-2025

1erg, 1erh, 1cdq, 1cdr, 1cds – hCD59 extracellular domain 26-102 – human - NMR
2ofs, 2j8b, 2uwr, 2ux2 – hCD59 extracellular domain
8cn6 – hCD59 extracellular domain + cyclic peptide
4bik, 5imt – hCD59 extracellular domain + intermedilysin
5imy – hCD59 extracellular domain + vaginolysin
6zd0 – hCD59 extracellular domain + cytolysin – Cryo EM
8b0f – hCD59 extracellular domain + C5b8 – Cryo EM
8b0g, 8b0h – hCD59 extracellular domain + C5b9 + 2C9 – Cryo EM

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Michal Harel, Alexander Berchansky