9b7a: Difference between revisions
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==Crystal structure of peroxiredoxin 1 with RA== | |||
<StructureSection load='9b7a' size='340' side='right'caption='[[9b7a]], [[Resolution|resolution]] 1.71Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9b7a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9B7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9B7A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ROA:(2R)-3-(3,4-DIHYDROXYPHENYL)-2-{[(2E)-3-(3,4-DIHYDROXYPHENYL)PROP-2-ENOYL]OXY}PROPANOIC+ACID'>ROA</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9b7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9b7a OCA], [https://pdbe.org/9b7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9b7a RCSB], [https://www.ebi.ac.uk/pdbsum/9b7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9b7a ProSAT]</span></td></tr> | ||
[[Category: Luo | </table> | ||
[[Category: Wu | == Function == | ||
[https://www.uniprot.org/uniprot/PRDX1_HUMAN PRDX1_HUMAN] Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Luo C]] | |||
[[Category: Wu Y]] | |||
[[Category: Xu H]] | |||
Latest revision as of 10:16, 22 January 2025
Crystal structure of peroxiredoxin 1 with RA
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