8y1y: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Crystal structure of the Mcl-1 in complex with a long BH3 peptide of BAK== | |||
<StructureSection load='8y1y' size='340' side='right'caption='[[8y1y]], [[Resolution|resolution]] 2.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8y1y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y1Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y1y OCA], [https://pdbe.org/8y1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y1y RCSB], [https://www.ebi.ac.uk/pdbsum/8y1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y1y ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Guo | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen Y]] | |||
[[Category: Guo M]] | |||
[[Category: Wang H]] | |||
[[Category: Wei H]] | |||
Latest revision as of 06:18, 29 January 2025
Crystal structure of the Mcl-1 in complex with a long BH3 peptide of BAK
| ||||||||||||
