8x4k: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8x4k is ~~ON HOLD until 2026~~-02-15

==Crystal structure of the glycosyltransferase domain of Legionella SetA in complex with UPDGlc==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8x4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X4K OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=8X4K FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=8x4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x4k OCA], [https://pdbe.org/8x4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x4k RCSB], [https://www.ebi.ac.uk/pdbsum/8x4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x4k ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/SETA_LEGPH SETA_LEGPH] Secreted effector that interferes with vesicular trafficking of host cells. Possesses glucohydrolase and mono-O-glucosyltransferase activity by using UDP-glucose as a sugar donor substrate. Is able to glucosylate histones H4 and H3.1 in vitro, but it is unlikely that histones are the natural substrates for SetA. May glycosylate a component of the host cell vesicle trafficking machinery during L.pneumophila infection. Binds with high specificity to phosphatidylinositol 3-phosphate (PtdIns(3)P), (with a dissociation constant value of 809 nM), which guides SetA to the cytosolic leaflet of the early phagosome of the host cell.<ref>PMID:19016775</ref> <ref>PMID:22288428</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Legionella pneumophila]]

[[Category: Hahn H]]

[[Category: Im HN]]

[[Category: Jang DM]]

[[Category: Kim HS]]

[[Category: Lee Y]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8x4k is ON HOLD  until 2026-02-15
+==Crystal structure of the glycosyltransferase domain of Legionella SetA in complex with UPDGlc==
+<StructureSection load='8x4k' size='340' side='right'caption='[[8x4k]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8x4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8X4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8X4K FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8x4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8x4k OCA], [https://pdbe.org/8x4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8x4k RCSB], [https://www.ebi.ac.uk/pdbsum/8x4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8x4k ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SETA_LEGPH SETA_LEGPH] Secreted effector that interferes with vesicular trafficking of host cells. Possesses glucohydrolase and mono-O-glucosyltransferase activity by using UDP-glucose as a sugar donor substrate. Is able to glucosylate histones H4 and H3.1 in vitro, but it is unlikely that histones are the natural substrates for SetA. May glycosylate a component of the host cell vesicle trafficking machinery during L.pneumophila infection. Binds with high specificity to phosphatidylinositol 3-phosphate (PtdIns(3)P), (with a dissociation constant value of 809 nM), which guides SetA to the cytosolic leaflet of the early phagosome of the host cell.<ref>PMID:19016775</ref> <ref>PMID:22288428</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Legionella pneumophila]]
+[[Category: Hahn H]]
+[[Category: Im HN]]
+[[Category: Jang DM]]
+[[Category: Kim HS]]
+[[Category: Lee Y]]