8w5d: Difference between revisions
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==Cryo-EM structure of Qb-Ab1== | |||
<StructureSection load='8w5d' size='340' side='right'caption='[[8w5d]], [[Resolution|resolution]] 4.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8w5d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_Qbeta Escherichia phage Qbeta] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W5D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W5D FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.3Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w5d OCA], [https://pdbe.org/8w5d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w5d RCSB], [https://www.ebi.ac.uk/pdbsum/8w5d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w5d ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A1_BPQBE A1_BPQBE] Minor capsid protein.<ref>PMID:21805520</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The germinal center (GC) sets an environment where antigen-specific B cells are compelled to continuously increase their affinity to compete for the antigen and obtain Tfh help for survival and propagation. Previous studies indicated that low-affinity B cells are disadvantaged in the presence of high-affinity ones, suggesting that competition may lead to the elimination of low-affinity B cells and their descendants. However, using a multivalent virus-mimicking antigen, our study demonstrates that low-affinity B cells not only successfully participate in GC responses alongside high-affinity B cells but also undergo accelerated affinity maturation under the more stringent competition. Furthermore, our cryo-electron-microscopy-based structural analysis reveals that both low-affinity and high-affinity B cells compete for the same antigenic epitope. Although the applicability of this idealized GC competition to true pathogen-induced responses remains uncertain, this change in perspective on the role of competition in low-affinity B cell evolution provides valuable insights for vaccine development. | |||
Competition propels, rather than limits, the success of low-affinity B cells in the germinal center response.,Li R, Bao K, Liu C, Ma X, Hua Z, Zhu P, Hou B Cell Rep. 2025 Feb 15;44(2):115334. doi: 10.1016/j.celrep.2025.115334. PMID:39955776<ref>PMID:39955776</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 8w5d" style="background-color:#fffaf0;"></div> | ||
[[Category: Bao | == References == | ||
[[Category: Hou | <references/> | ||
[[Category: Li | __TOC__ | ||
[[Category: Zhu | </StructureSection> | ||
[[Category: Escherichia phage Qbeta]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Bao KY]] | |||
[[Category: Hou BD]] | |||
[[Category: Hua ZL]] | |||
[[Category: Li RH]] | |||
[[Category: Zhu P]] | |||
